Cycloadditions In Biological Systems Promoted By Strained Pi-bonds

Tech ID: 17469 / UC Case 2005-033-0

Abstract

The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 1,043,4111 10/08/2019 2005-033
United States Of America Issued Patent 9,260,371 02/16/2016 2005-033
United States Of America Issued Patent 8,461,298 06/11/2013 2005-033
United States Of America Issued Patent 8,431,558 04/30/2013 2005-033
United States Of America Issued Patent 7,807,619 10/05/2010 2005-033
United States Of America Published Application 20200046742 02/13/2020 2005-033
 

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Keywords

Copper-free, click chemistry

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