Identification of Mutations in the Gene CMAH that causes the Cat Blood Type B
Domestic cats have one major blood group system with three different types: A, B and the rare AB. The two major serotypes are blood type A and type B, with type A dominant to type B. The rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood typing is important mainly for two reasons: to avoid neonatal isoerythrolysis (NI) that can occur in newborn kittens, and to avoid reactions for blood incompatibility when the cat needs a blood transfusion. These reactions, which may vary in severity from mild to fatal, are due to naturally occurring antibodies. Thus, prevention of NI and transfusion reactions requires close monitoring of blood types.
Researchers at the University of California, Davis have identified a series of mutations in the gene CMAH that distinguish type A from type B and are 100% concordant with all cats serotyped. Furthermore, UC Davis researchers have developed a genetic test to distinguish between the blood type A cats and the ones that are carriers for the B blood type allele, which is impossible with serological tests.
This genetic test can be used for typing domestic cat blood.
Even though accurate tests are readily available to determine feline blood types, the development of a genetic test has the following advantages:
|United States Of America||Issued Patent||7,985,543||07/26/2011||2007-264|