Targeted Delivery to the Heart Endothelium

Tech ID: 11237 / UC Case 2008-157-0


Targeted delivery of nanoparticles to the heart endothelium with large pay-load potential, applicable to drug/gene delivery.

Full Description

Ligand-targeted liposomes are increasingly being recognized as an effective strategy to deliver drugs to specific organs; however, few studies have quantified endothelial binding of targeted liposomes. Researchers at the University of California, Davis have discovered that embedding high concentrations of short, linear, arginine-terminated peptides into nanoparticles allows for concentrated binding of the particles selectively to heart endothelium and the vascular endothelium in the heart.


  • Targeted drug delivery vehicles
  • Contrast agents for imaging


  • No other methods exist currently to deliver drugs or genes specifically to the heart endothelium

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 8,506,928 08/13/2013 2008-157


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  • Ferrara, Katherine W.
  • Kusunose, Jiro
  • Zhang, Hua

Other Information


cardiovascular system, cardiac, cardiac endothelium, heart muscle, drug delivery, targeted, nanoparticles, nanodroplets, imaging

Categorized As