Marine Organism Yields a Patented Family of Antitumor/Antibiotic Compounds
Tech ID: 19299 / UC Case 2003-248-0
BackgroundActinomycetes are well known soil bacteria that were once believed to occur in the ocean only when washed in from land. Today, it is clear that unique populations of marine actinomycetes reside in ocean sediments and that these bacteria are fundamentally different from those on land. Although terrestrial actinomycetes have been the source of many of today's more than 120 drugs, marine actinomycetes have only recently been incorporated into the discovery process. These bacteria are now proving to be a particularly rich source of unique natural products, many of which display potent biological activities.
Researchers at the Scripps Institution of Oceanography have discovered a new group of marine actinomycetes that have tentatively been called MAR2. These bacteria produce unique, polyketide-derived macrolides including a series of compounds called marinomycins A-D, which were discovered from the MAR2 strain CNQ-140 (Kwon et al., 2006). These compounds possess potent antibiotic and antitumor properties.
- Novel class of molecules may provide antibiotics against MDR-bacteria in humans as well as domestic and farm animals.
- Compositions may provide new drugs for single or combination therapy versus various cancers.
An issued patent includes:
- Broad claim for cyclic polyene-polyols, which are strengthened by exact specification of six compositions of matter.
- Broad claims for methods of use as antitumor and antibiotic drugs.
State Of Development
In vitro data demonstrates:
- Significant antimicrobial activity against numerous drug-resistant bacterial pathogens, including S. aureus, E. faecium and C. albicans.
- Impressive and selective cancer cell cytotoxicity against six of eight melanoma cell lines in the NCI’s 60-cell line panel.
See also U.S. patent 7,521,414.
- Scripps Marine Chemist Receives Highest Award in Natural Products Chemistry
- Fenical Research Group
- Kwon HC, Kauffman CA, Jensen PR, Fenical W. 2006. Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "Marinospora." J. Amer. Chem. Soc. 128:1622-1632.
|United States Of America||Issued Patent||7,521,414||04/21/2009||2003-248|
- Disease: Autoimmune and Inflammation
- Disease: Cancer
- Disease: Cardiovascular and Circulatory System
- Disease: Central Nervous System
- Disease: Dermatology
- Disease: Infectious Diseases
- Disease: Kidneys and Genito-Urinary System
- Disease: Metabolic/Endocrinology
- Disease: Ophthalmology and Optometry
- Disease: Respiratory and Pulmonary System
- New Chemical Entities, Drug Leads
2003-248-0, 2010-329-0, 2006-079-0, 2010-351-0
NCE, chemical entity, chemical entities, composition, marine, tumor, cancer, carcinoma, oncology, antibiotic, infection, infectious, melanoma, therapeutic, polyketide, macrolides, MAR, MDR, drug resistant