The technology is a method to grow glioblastoma (or other cancer) cells in cortical organoids. The technology encompasses methods for culturing primary patient-derived cancer cells, screening candidate agents for activity in reducing cancer cell growth and inhibiting the invasion of cancers of the central nervous system.
Current methods to grow glioblastoma in culture involve tumor explants (i.e., cells grown in culture dishes) or neuroblast culture. It is challenging to grow and study glioblastoma as few cells from primary patient tumors survive and/or exhibit poor grown either in cell culture or when transplanted into mouse models.
-primary tumors to be studied without substantially changing the underlying tumor cell types.-study of the whole tumor population (current methods involve selective processes that grow out of specific tumor clones).-sorting of desired tumor populations and subsequent culturing (current methods typically result in death of many cell populations)
To commercialize the technology
Proof of concept – method utilized to culture sorted and unsorted tumor populations
|Patent Cooperation Treaty
|Reference for National Filings
PCT patent application No. WO2021138209A1