Novel Citrus Genetic Immune Regulators For Defense Against Huanglongbing Disease

Background

Huanglongbing (HLB), which is caused by the bacteria ‘Candidatus’ Liberibacter asiaticus’ (CLas) and is vectored by the Asian citrus psyllid (ACP), is the most devastating citrus disease and has resulted in a significant reduction in citrus quality and quantity. HLB causes billions of dollars in losses of citrus products every year, and seriously impacts the viability of the citrus industry. Currently there are no commercially known HLB disease control methods that are efficient and sustainable.

Brief Description

Prof. Hailing Jin and colleagues from the University of California, Riverside have identified genetic negative immune regulators that control the natural immune responses in citrus against HLB. Decreasing or removing these immune regulators may lead to citrus plants that are tolerant and/or resistance to HLB. The development of HLB resistant citrus plants is less expensive and a more efficient long term solution compared to current HLB management strategy, which includes removing infected trees and/or applying pesticides to lower the ACP population.

Fig 1:Nicotiana benthamiana (Nb) model plants after exposure to HLB-like infection for 5 days. The plant with its VAD gene knocked-down (siVAD) expresses resistance to the HLB-like infection. The control plant (iRB control) is pictured on the left and is less resistant to the HLB-like infection. 

Application

The creation of citrus plants that are tolerant and/or resistant to HLB.

Patent Status

Related Materials

• Huang CY, et. al, Identification of citrus immune regulators involved in defence against Huanglongbing using a new functional screening system. Plant Biotechnol J. 2021 Apr;19(4):757-766. doi: 10.1111/pbi.13502. Epub - 10/27/2020