T Cell Receptor cDNAs to Treat Gliomas

Tech ID: 32233 / UC Case 2017-067-0

Technology Description

Mutations in the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 are frequently found in gliomas. Mutations in an HLA-class II binding CD4 T-cell epitope of IDH1, termed IDH1R132H, are present in 70-80% of WHO grade II and III glioma patients. In collaboration with Berlkeley Lights Inc., scientists at UCSF have recently cloned cDNAs that code for T-cell receptors that react with a peptide derived from isocitrate dehydrogenase 1 mutated at residue 132 (IDH1R132H). Immunizing mice bearing IDH1R132H-transfected syngeneic sarcomas with the IDH1R132H peptide was shown to have an anti-tumor effect. The cDNAs developed can, therefore, be used to develop adoptive T-cell therapies for cancers bearing the IDH1R132H mutation.

ADVANTAGES

  • The new T cell receptors can recognize IDH proteins that are mutated in most gliomas
  • Can improve the design of safe and effective cancer immunotherapy
  • Cancer immunotherapy targeting IDH1R132H has the potential to be more effective than vaccination

Patent Status

Country Type Number Dated Case
European Patent Office Published Application 2017-067
Patent Cooperation Treaty Published Application WO2019157279 08/15/2019 2017-067
 

Additional Patent Pending

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Keywords

T Cell Receptor, Adoptive Cell Therapy, Glioma, Isocitrate Dehydrogenase, Cancer Immunotherapy

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