Steroid Regulation Of Inwardly Rectifying K+ Channel As Therapeutics Tool

Tech ID: 31783 / UC Case 2020-081-0

Patent Status

Patent Pending

Brief Description

UC Berkeley researches have discovered a new physiological modality of a potassium channel that is linked to the process of fluid regulation in the brain and is expressed in the choroid plexus (CP) and retinal pigment epithelia. CP is the main producer of cerebrospinal fluid that serves as a buffer to protect the brain, provides it with nutrients and removes waste products. The researchers have shown that application of progesterone resulted in strong potentiation of the inwardly rectifying potassium channel. The potentiation was progesterone-specific and independent of other known membrane progesterone receptors expressed in CP. 

Suggested uses

  • The treatment of cerebral spinal fluid malfunctions and various eye disorders


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  • Lishko, Polina V.

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