Osterix Specific Peptides for Treatment of Osteoporosis and Reversal of Bone Degradation

Tech ID: 29719 / UC Case 2016-823-0

Abstract

Researchers at the University of California, Davis have developed osterix-targeting peptides to prevent premature drug release during circulation, and deliver high concentration and time-depended release of drug treatments to bone defective sites.

Full Description

Osteoporosis, a disease that increases bone fragility, results from estrogen deficiency and aging. Current treatments for osteoporosis tend to reduce bone loss by decreasing osteoclastic bone resorption, which prevents further breakdown of bone. However, these treatments do not restore the lost bone structure of the patient or work to increase bone formation.

Researchers at the University of California, Davis have developed osterix-targeting peptides to prevent premature drug release during circulation and deliver high concentration and time-depended release of drug treatments to bone defective sites. This method increases osteogenesis in vitro and in vivo, promoting bone formation and increasing bone mass. In addition this treatment takes advantage of high-affinity, bone targeting, peptide ligands to achieve affinity and therapeutic potential to activate or inhibit a signaling pathway. By using this compound the treatment has advantage over other conventional drug treatments of osteoporosis by limiting off-target effects and requiring less frequent dosing. This type of drug loading system is not only fine-tunable in nature, but also uses highly reproducible structures and properties to treat bone loss, or repair both non-union fractures and osteoporotic fractures that fail to heal.

Applications

  • Osterix-targeting peptides to prevent premature drug release during circulation
  • Time-depended release of drug treatments to bone defective sites

Features/Benefits

  • Well-defined bone-seeking agent
  • Tissue specific bone targeted delivery
  • Specifically targets osteoblast differentiation
  • Sterix targeting
  • Cell specificity
  • Specific signaling activator

Patent Status

Patent Pending

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Other Information

Keywords

Osteoclastic, osteogenesis, bone formation, bone mass, drug delivery, fractures, osterix-targetting, osteoporosis

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