Heterochronic Blood Exchange As A Modality To Influence Myogenesis, Neurogenesis, And Liver Regeneration

Tech ID: 27121 / UC Case 2017-049-0

Patent Status

Patent Pending

Brief Description

One reason for waning capabilities with advancing age is a progressive decline in organ function. Heterochronic parabiosis rejuvenates the performance of old tissues' stem cells at some expense to the young, but whether this is through shared circulatory factors or shared organ systems is unclear; and parabiosis is not a clinically adaptable approach. The old heterochronic partners have access to young organs, environmental enrichment and youthful hormones/pheromones, while the young parabiont maintains an additional aged body with deteriorating organs.

In contrast to the permanent anastomosis of parabiosis, UC Berkeley researchers have used a small animal blood exchange where animals are connected and disconnected at will, removing the influence of shared organs, adaptation to being joined, etc. The effects of heterochronic blood exchange were examined with respect to all three germ layer derivatives: injured-regenerating muscle, ongoing liver cell proliferation and brain - hippocampal neurogenesis, and in the presence and absence of muscle injury.  The influence of heterochronic blood exchange on myogenesis, neurogenesis and hepatogenesis was fast, within a few days.  These findngs suggest a rapid translation of blood apheresis (FDA approved for other diseases, but not for the degenerative pathologies) for therapy to attenuate and reverse liver fibrosis and adiposity, muscle wasting and neuro-degeneration.

 

Suggested uses

  • use  in clincal patients to induce rapid liver regeneration, reduction of fibrosis, muscle healing post-injury or immobility, or old age.
  • enhance neurogenesis, brain health, muslce regeneraiton,hepatogenesis and liver health, as well as physical performance and cognitive ability

Advantages

  • removal of "old blood components" is far more effective than adding young blood or blood component to the aged mammal
  • enhances old muscle repair without inhibition of young,
  • old hepatogenesis is improved and fibrosis and adiposity are decreased, while young hepatogenesis becomes diminished
  • rapid increase in beta-2 microglobulin (B2M) in young tissues by old blood

Publication

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

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Inventors

  • Conboy, Irina M.

Other Information

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