Compositions and Methods for Inhibiting Stem Cell Aging

Tech ID: 26036 / UC Case 2017-015-0

Patent Status

Country Type Number Dated Case
Patent Cooperation Treaty Published Application WO2018039371 03/01/2018 2017-015

Additional Patents Pending

Brief Description

By 2050 the number of people in the world that will be aged 65 or older is expected to nearly triple to about 1.5 billion, representing 16% of the world’s population. One aspect of aging involves a diminished capacity to repair tissues after injury. This diminished capacity is evident in certain conditions that occur with aging, such as anemia, sarcopenia (loss of muscle mass), and osteoporosis. Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance. Adult stem cells mostly reside in a metabolically inactive quiescent state to preserve their integrity, but convert to a metabolically active proliferative state to replenish the tissue. The signals that trigger stem cells to exit the cell cycle and re-enter quiescence, and the signal transduction leading to the transition remain elusive however.


UC Berkeley researchers have developed methods of reducing or inhibiting or reversing stem cell aging or preventing and/or reversing tissue degeneration or injury by increasing the activity and/or the level of SIRT2 in an adult stem cell or reducing the level of a nucleotide-binding domain and leucine-rich repeat- containing-3 (NLRP3) polypeptide in an adult stem cell.


Suggested uses

  • Drug targets for the treatment of aging diseases or tissue degeneration or injury
  • Study of age-related diseases


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  • Chen, Danica

Other Information


aging, stem cell, tissue degeneration

Categorized As

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