Disease Treatments Using Multimeric TNFSF Ligands

Tech ID: 19475 / UC Case 1999-003-0

Technology Description

UCSD researchers have developed an invention useful for:

  1. augmenting immunity (both cellular and antibodies) against cancer and infectious diseases
  2. Expanding immune cells (B cells, dendritic cells, macrophages and T cells) in vitro for reinfusion of them or their products
  3. Immunological testing of immune function. In one embodiment, the invention is a soluble recombinant fusion protein containing multiple CD40 ligands ("CD40L").
This protein affects macrophages and B cells in the same manner as membrane CD40L. The same technology can be applied to produce other members of the TNF family, such as TNF-alpha, FasL, TRAIL, RANKL, 4-1BBL, and others.

Advantages

The advantages of this new form of CD40L are:

  • Versatile - treatment for cancer and infectious disease agents such as HIV and Mycobacterium tuberculosis; vaccines; expanding immune cells; and diagnostic tests of immune function; may have utility in neutralizing autoimmune response in diseases such as lupus or multiple sclerosis.
  • Potent - affects macrophages and B cells in the same manner as membrane CD40L.

Contact

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Inventors

  • Kornbluth, Richard S.

Other Information

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