Vesosome: A Versatile Multi-Compartment Structure For Targeted Drug Delivery

Tech ID: 19353 / UC Case 1997-024-0

Brief Description

An extremely versatile drug delivery system composed by a lipid-bilayer vesicle.

Background

Vesicles of lipid bilayers are useful structures for drug delivery. The permeation rate, membrane charge, specific recognition particles, steric stabilizers, membrane rigidity, and phase transition temperatures all play a role in optimization of vesicles for particular delivery applications. Currently, vesicle design is restricted by conflicts among these properties, forcing trade-offs in the design of vesicle delivery systems.

Description

Researchers at the University of California have constructed vesosomes by aggregating lipid-bilayer vesicles using biotin-streptavidin complexation and then encapsulating these aggregates in a larger lipid bilayer using the same molecular-recognition technique. These multi-compartment vesosomes offer a versatile means for designing delivery systems because they can distribute often incompatible attributes among the various membranes. Interior vesicle sizes range from 20-500 nm and vesosome sizes range from about 0.1 micron to greater than 1.0 micron.

 

 

Vesosome2
 

 

Advantages

The vesosome's multi-vesicle and self-assembly properties permit:

  • Division of incompatible membrane properties among the various membranes, allowing the possibility for sophisticated drug-delivery schemes
  • Optimization of bilayer composition and aggregate size at each step of the self-assembly process.

Applications

  • Extremely versatile drug delivery systems
  • Chemotherapy

 

The technology is available for licensing.

 

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 6,221,401 04/24/2001 1997-024
 

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Inventors

  • Coldren, Bret
  • Kennedy, Michael T.
  • Kisak, Edward
  • Walker, Scott A.
  • Zasadzinski, Joseph A.

Other Information

Keywords

drug delivery, targeted, vesicle, chemotherapy, indpharma

Categorized As