An extremely versatile drug delivery system composed by a lipid-bilayer vesicle.
Vesicles of lipid bilayers are useful structures for drug delivery. The permeation rate, membrane charge, specific recognition particles, steric stabilizers, membrane rigidity, and phase transition temperatures all play a role in optimization of vesicles for particular delivery applications. Currently, vesicle design is restricted by conflicts among these properties, forcing trade-offs in the design of vesicle delivery systems.
Researchers at the University of California have constructed vesosomes by aggregating lipid-bilayer vesicles using biotin-streptavidin complexation and then encapsulating these aggregates in a larger lipid bilayer using the same molecular-recognition technique. These multi-compartment vesosomes offer a versatile means for designing delivery systems because they can distribute often incompatible attributes among the various membranes. Interior vesicle sizes range from 20-500 nm and vesosome sizes range from about 0.1 micron to greater than 1.0 micron.
The vesosome's multi-vesicle and self-assembly properties permit:
The technology is available for licensing.
|United States Of America||Issued Patent||6,221,401||04/24/2001||1997-024|
drug delivery, targeted, vesicle, chemotherapy, indpharma