Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase

Tech ID: 18881 / UC Case 2002-460-0

Background

Technology Description

University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric oxide (NO). X-ray crystallography was utilized to generate isoform specific NOS-inhibitor complexes with unique structural characteristics. An overproduction of NO has been linked to several diseases, conditions and addictions, including: ischemic injury and other brain damage after stroke, migraine headache, Alzheimer's Disease, colitis, tissue damage, inflammation, septic shock and rheumatoid arthritis.

Applications

This discovery provides for drug discovery and design protocols for isoform drugs that target NOS isoforms and reduce NO production.

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 7,056,945 06/06/2006 2002-460
 

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