Cell Lines And Transgenic Mice Containing Fatty Acid Synthase Promoter-luciferase Constructs

Abstract

Fatty acids synthase (FAS) plays a central role in de novo lipogenesis in mammals and birds. FAS activities and concentrations in animals? liver and adipose tissues are subjective to nutritional and hormonal manipulations.

This disclosure relates to cell lines and transgenic mice containing fatty acid synthase promoter-luciferase constructs.

References:

D Wang & HS Sul. 1995. Upstream Stimulatory Factors bind to Insulin Response Sequence of the Fatty Acid Synthetase Promoter. JBC. 270:28716-22.

M Soncini, SF Yet, Y Moon, JY Chun, & HS Sul. 1995. Hormonal and Nutritional Control of the Fatty Acid Synthetase Promoter in Transgenic Mice. JBC. 270:30339-43.