Hybridomas Producing Monoclonal Antibodies To Basal Transcription Factors

Abstract

Regulated transcription requires specific interactions between activators bound to promoter sequences and other components of the RNA polymerase transcriptional machinery. These factors (TATA-binding protein Associated Factors [TAFs]) serve to mediate transcriptional activations


UCB scientists have developed hybridomas producing monoclonal antibodies to:

Drosophila TAFS 250, 150, 110, 80,60,40, 30alpha, 30beta

and Human TAFS 250,130,100


References:

The EMBO J (1993) v12 pp5303-9

Science (1994) v263 pp811-4

Genes & Dev. (1993) v7 pp2587-97