Hybridoma (17b5), Producing Monoclonal Antibody Specific For Mouse 4-1bb

Abstract

This invention concerns a hybridoma producing a hamster IgG monoclonal antibody specific for the mouse 4-1BB receptor. Mouse 4-1BB is a member of the TNF receptor gene family of receptors. It is expressed by activated T cells in mice. We found that 70-80% of IL-2 activated NK cells also stain with our anti-4-1BB antibody. It has been reported that 4-1BB is a ?co stimulatory? receptor on T cells. When injected into mice, 17B5 antibody against 4-1BB can promote protection against certain transplanted tumor cells.

Applications

The antibody is useful for staining the T cells and/or the NK cells that express the mouse 4-1BB receptor.
The antibody may induce signaling in lymphocytes, since it augments tumor immunity.

Advantages

This 4-1BB antibody may signal differently than other available antibodies as it exhibits superior functional activity.