Method for Regulating Apoptosis

Tech ID: 11335 / UC Case 2003-504-0

Abstract

Method for inhibiting cellular apoptosis through the regluation of mitochondrial fission.

Full Description

A method for inhibiting cellular apoptosis through the regulation of mitochondrial fission and fusion has been identified by researchers at the University of California, Davis. The method for identifying small molecule inhibitors of mitochondrial fission fusion is described. Such compounds can be capable of regulating cellular apoptosis via their effects on mitochondrial membrane dynamics.

UC Davis investigators have verified compound activities in both yeast and mammalian cell systems. Studies have indicated that one compound acts through the mediation of the mitochondrial fission dynamin related GTPase. In addition, UC Davis researchers have discovered that a small molecule inhibitor of Drp1, the mitochondrial division dynamin, blocks the mitochondrial outer membrane permeabilization in isolated mitochondria, the first step in apoptosis induced by truncated Bid (tBid). The new compound is termed mdivi-1.

Applications

  • Treat conditions associated with apoptosis
    • Mycocardial infarction, cancer, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and and neurodegenerative diseases

Features/Benefits

  • High degree of conservation among fission and fusion proteins
  • Alternative target for therapeutic attenuation of apoptosis
  • Target dynamins and thus prevents cells from dying

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 8,450,333 05/28/2013 2003-504
 

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Inventors

  • Cassidy-Stone, Ann
  • Kurth, Mark J.
  • Nunnari, Jodi

Other Information

Keywords

mdivi-1, Drp1, apoptosis, myocardial infarction, stroke

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