Efficient Production of 14C-Vitamin B12 for Human Microdosing and Other Applications
A novel and an efficient method for producing isotopically-labeled forms of vitamin B12 (cobalamins) has been developed by scientists at the University of California, Davis. This invention is coupled to the development of a new set of clinical and diagnostic technologies related to vitamin B12 deficiency and metabolism.
Determination of 57Co-B12 is not particularly sensitive or quantitative (i.e., The Schilling Test). In addition, the half-life of 57Co makes it expensive to handle and dispose of properly and radiation dosage exposure to workers, patients, and environment is significant.
Our new method overcomes the problems associated with the Schilling Test by using 14C-B12 as the label.
Appearance of carbon-14 Vitamin B12 in human plasma. Detection is by mass spectrometry
The key novel features of this method are:
|United States Of America||Issued Patent||8,202,507||06/19/2012||2005-050|