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Mid-pregnancy Serum Biomarkers for Predicting Preterm Birth

This mid-pregnancy serum biomarker test can accurately and effectively identify pregnancies that will deliver before 32-weeks of gestation.

A Mouse Model of Human Papillomavirus (HPV) infection for Drug Discovery

UCSF researchers have generated and validated a K14-HPV16 transgenic mouse model, in which transgene expression produces neoplastic progression that fully resembles the gynecological and other epithelial dysplastic lesions induced by high risk HPVs. This model offers an invaluable tool for studying HPV infection and developing new drugs for HPV treatment.

HIGHLY SPECIFIC DIAGNOSTIC CLASSIFIERS OF ENDOMETRIOSIS

This invention provides a non-invasive method to detect endometriosis in women through the use of novel diagnostic biomarkers that detect the presence, absence, and/or severity of endometriosis.

NOVEL DRUG DELIVERY DEVICE FOR PATIENTS AT RISK FOR BREAST CANCER

This novel device enables the localized, controlled delivery of chemopreventative agents to the breast tissue of patients at risk for developing breast cancer. 

Novel Non-Invasive Biomarkers For Oocyte/Early Stage Embryo Competence

Infertility affects about 10% of couples in the United States, and the cause of infertility in up to 30% of affected couples remains unexplained. In Vitro Fertilization (IVF) is the most commonly used Assisted Reproductive Technique to address the issue of infertility in couples; however, the low IVF success rates (30-40% for women aged 34 and younger, with decreased success rates for older women) reveals a need for methods to accurately predict IVF success. Current methods for predicting IVF success use pre-implantation genetic diagnosis or morphological assessment of oocytes. However, pre-implantation genetic diagnosis requires embryo biopsy and does not improve live-birth success rate. In addition, morphological assessment is subjective and unquantitative, and often fails to predict IVF success. Therefore, the development of new methods to predict oocyte competence that are non-invasive, quantitative, and accurate would represent a great advance in the field.

Novel, reliable, non-invasive and inexpensive assay to detect steroids

Researchers at UCSF have developed a novel method that can detect and measure the total activity of any steroid from urine in under two days. The assay leads to reproducible results and measurements can be easily automated.

NOVEL PRENATAL DIAGNOSTIC BIOMARKERS FOR CYTOMEGALOVIRUS INFECTION

UCSF researchers have identified novel biomarkers of CMV replication that permit early detection of virus transmission before the onset of symptomatic disease. Quantification of these biomarkers is a more sensitive and reliable method than detection of viral DNA and therefore could result in novel tests for diagnosis of congenital infection in early gestation. Additionally, these biomarkers could be used to measure efficacy of treatment in pregnancies at high risk for congenital CMV disease and to serve as endpoints for successful antiviral therapy.

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