Abstract

Researchers at the University of California, David have discovered a new and more rapid method for predicting response to therapy in cancer patients with a non-invasive, highly specific optical imaging technique.

Full Description

This new imaging approach provides a rapid, non-invasive test of the cancer's response to chemo and molecular targeted therapies, including the detection of drug resistance cells.  The imaging approach is based on optical measurement of changes in metabolic activity of individual cells, upon exposure to cancer therapies.  The imaging approach is significantly more sensitive than existing imaging methods and histo-culture drug response assays.  This approach can be implemented for both ex-vivo clinical tissues, cells and in-vivo imaging.  Changes induced by drugs in individual cancer cells within tissues can be measured in less than 2 hours.  In addition, measurements can also be conducted using flow cytometry and point of care devices such as microfluidics lab on chip devices.

Applications

• Ability to detect small fractions of drug resistant cells within tumors
• Single-cell imaging of clinical isolates, intact tissues, and in-vivo imaging
• Detection of response to chemotherapies and molecular targeted therapies
• More rapid analysis than conventional assays
  

Features/Benefits

• Cancer treatment assessment
  

Inventors

• Luo, Zhen
• Nitin, N

Other Information

Contact

Nancy E. Rashid / nerashid@ucdavis.edu / tel: View Phone Number. Please reference Tech ID #22458.

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