Hydrolytically Degradable Poly(ethylene glycol) Derivatives for Use in Pharmaceutical Formulations
Tech ID: 22412 / UC Case 2012-315-0
A novel hydrolytically degradable polyethylene glycol derivative for use in pharmaceutical and cosmetic formulations.
Polyethylene glycol (PEG) is a polyether compound with many applications from personal care to medicines. It is commonly attached to a drug or therapeutic protein in order to improve the bioavailability and associated stability of the drug. PEG in pharmaceutical applications is not usually degradable, narrowing the overall scope for its usage. Functionalization of PEG is also difficult as only the chain end groups can be exploited.
Researchers at the University of California, Santa Barbara have developed a novel hydrolytically degradable polyethylene glycol derivative for use in pharmaceutical and cosmetic formulations. These PEG derivatives significantly boast control over the circulation half-life of PEG-incorporated drugs while allowing complete clearance from the body even at very high molecular weights. These PEG derivatives are simple and inexpensive to create with the degradable units further serving as reactive groups for therapeutic and diagnostic applications. These units also increase the range and overall number of functionalization sites, increasing pharmaceutical usefulness and patentability.
- Excellent hydrolytic behavior
- Inexpensive and simple to manufacture
- Accurately controlled PEG molecular weight before and after degradation
- Degradable units serve as reactive groups for therapeutic and diagnostic applications
- Control over circulation half-life of PEG-incorporated drugs
- Pharmaceutical and cosmetic formulations
- Drug manufacturing and research
- Therapeutic drugs with improved circulation half-lives
- Controlled delivery of protein drugs.
This technology is available for licensing.
- Hawker, Craig J.
- Lee, Bongjae
- Lundberg, Pontus
- Lynd, Nathaniel A.
- Pressly, Eric D.
- van den Berg, Sebastiaan A.
PEG, Pharmaceutical, Diagnostic, Degradable, Drug
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