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Early Diagnosis and Treatment for Citrus Greening Disease

University of California, Riverside researcher, Prof. Hailing Jin, has shown that several citrus small RNAs are induced upon infection by Candidatius Liberibacter asiaticus (Las).  These miRNAs and siRNAs would enable the early diagnosis of HLB in citrus trees and nursery stocks.  In addition to the identification of the miRNA biomarker, Prof. Jin also discovered that treating Las infected trees with phosphorus oxyanion improved fruit production.  These studies of the improvement in yield in HLB infected citrus was demonstrated in a 3-year field trial in Florida.  Fig. 1 shows the relative expression levels of miRNA399 in HLB infected citrus. Infected trees express high levels of miRNA 399. Fig. 2 shows leaves from trees that did or did not receive phosphorus oxyanion treatment over a one year period. Leaves treated with phosphorus oxyanion are healthier than leaves from untreated trees.

A General Solution-Processable Approach To High-Quality Two-Dimensional Ink Materials For Printable High-Performance Large-Area And Low-Cost Electronics/Optoelectronics/Thermoelectrics

UCLA researchers in the Departments of Chemistry & Biochemistry and Materials Science & Engineering have developed a general and cost-effective solution-phase approach to create large-area and high-performance thin films or devices.

Nanoparticulate Mineralized Collagen Glycosaminoglycan Scaffold With An Anti-Resorption Factor

Researchers in the Division of Plastic and Reconstructive Surgery at the UCLA David Geffen School of Medicine have developed novel methods to incorporate anti-resorption factor into nanoparticulate mineralized collagen glycosaminoglycan scaffold to maximize bone regeneration.

Gene Editing Stem Cells For Generating Non-Alloreactive T Cells For Immunotherapy

UCLA researchers in the Department of Pathology and Medicine have developed human stem cells that can be used to generate non-alloreactive, antigen specific T cells for adoptive cell therapy.

3D Scaffolds For Mesoderm Differentiation

Researchers led by Benjamin Wu from the Departments of Bioengineering and Pathology & Laboratory Medicine have developed an implantable scaffolding that can create hematopoietic stem cells from pluripotent stem cells in vivo.

Bioengineered Thymic Aggregates For Implantation

Researchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.

Ion-Gated Thermal/Electrical/Optoelectronic Modulator/Transistors/Switches

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel device for modulating thermal and electrical properties of materials by manipulating ionic motions.

Reagent to Label Proteins via Lysine Isopeptide Bonds

Researchers in the UCLA Department of Chemistry and Biochemistry and the University of Texas-Medical Center, Houston Department of Microbiology and Molecular Genetics have modified the Corynebacterium diphtheriae (C. diphtheriae) sortase enzyme so that it can be used as a bioconjugation reagent in vitro.