3D-Bioprinted All-Inclusive Bioanalytical Platforms for Cell Studies

Tech ID: 32123 / UC Case 2020-674-0

Brief Description

Common drug screen models, such as animals and 2D cell cultures, do not properly recapitulate human organ structure and environment. Using 3D bioprinting technology, researchers at UCI have developed all-inclusive customized organ-on-a-chip-like platforms. These platforms produce cell models that properly mimic the microenvironment of cells for drug screening and cell-therapeutic response studies.

Suggested uses

·Assays in which there is a need to mimic cell viability, metabolic activity, and the vital reactions of organs or tissues

·Drug screening and therapeutic response assays

Features/Benefits


  • Accurate: The miniaturized biomimetic representation of cell models when interconnected together with microfluidic technology can capture complex human physiology in vitro
  • Efficient: Rapid prototyping of microfluidic cell handling arrays in different geometries
  • Consistency: 3D printers have high repeatable performance compared to other prototyping technologies
  • Timesaving: The ability to deposit scaffold, polymer materials, and cells simultaneously or consecutively

Technology Description

The approval of a new therapeutic requires testing in numerous models. However, cell culture and animal models can be insufficient, particularly in representing disease, due to the simplicity of the system and species differences respectively. In recent years, several principles and technologies such as 3D-tissue and organ culture have merged with 3D-printing and microfluidic approaches to create a more accurate representation of cell models and reflect complex human physiology in vitro. These platforms are referred to as "organ-on-a-chip" (OOC) devices. Unfortunately, the currently available OOC devices have been hindered due to manufacturing challenges, including the expense of fabrication systems. Lower cost manufacturing methods, such as laser cutting and molding, result in low resolution platforms that inadequately represent organ systems.

UCI researchers have adapted the 3D-bioprinting technology to develop multiple high throughput, customizable organ-on-a-chip-like platforms along with printed 3D-cell structures. These single-step platforms allow rapid (5 minute), inexpensive, and tailorable design production of microfluidic devices with a variety of dimensions, allowing consistent and efficient investigation of therapeutic responses.

State Of Development

Conceptual and experimental testing

Patent Status

Patent Pending

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Inventors

  • Esfandyarpour, Rahim

Other Information

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