Targeting Tet2, And Associated Signaling Pathways, For Amelioration Of Cognitive And Regenerative Dysfunction During Aging.
Tech ID: 32053 / UC Case 2018-082-2
This invention identifies the enzyme ten eleven translocation methylcytosine dioxygenase 2 (Tet2), and its associated signaling pathways, for the amelioration of cognitive and regenerative dysfunction during aging. This pre-clinical finding describes compositions and methods of increasing Tet2 to reverse age-related decline in adult neurogenesis and enhance cognition in all populations.
The molecular mechanisms mediating cognitive and neurogenic rejuvenation remain elusive, however, this finding:
- identifies Tet2 and associated downstream signaling pathways as targets for the amelioration of age-related cognitive and regenerative dysfunction.
- suggests specific modulators of Tet2 as a preventative, therapeutic and/or restorative agent.
- provides an unconventional approach for ameliorating normal aging processes and age-related cognitive disorders in the elderly, including Alzheimer’s disease and dementia.
- shows that preventative strategies can be initiated at young adult ages.
Stage of Development
- Gontier, G., Iyer, M., Shea, J. M., Bieri, G., Wheatley, E. G., Ramalho-Santos, M., & Villeda, S. A. (2018). Tet2 rescues age-related regenerative decline and enhances cognitive function in the adult mouse brain. Cell reports, 22(8), 1974-1981.
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