Fragment-Based Stabilization Of 14-3-3/Client Protein-Protein Interactions

Tech ID: 31712 / UC Case 2020-117-1

Invention Novelty

UCSF and Technical University of Eindhoven investigators have identified molecular fragments that stabilize 14-3-3/phospho-peptide and 14-3-3/phospho-protein interactions.  Further structure-guided and empirical medicinal chemistry will lead to a drug lead for the most advanced target (estrogen receptor).  

 

Value Proposition

Systematic approaches to stabilizing protein-protein interactions are nonexistent in the literature; this particular focus on 14-3-3/client complexes allows researchers to address many high-value targets in oncology, neurodegeneration, inflammation, and metabolism.

 

Technology Description

To date, the demonstration of the discovery/linking method is unique for this target and for stabilizing protein-protein interactions in general.  By identifying the underlying rules for molecular recognition of 14-3-3/clients by small molecules, these hit compounds may also be starting points to discover stabilizers for new 14-3-3/client complexes.

 

Looking for Partners

To develop & commercialize the technology for drug development.

 

Stage of Development

Proof of Concept

 

Data Availability

Under CDA

 

Contact

Learn About UC TechAlerts - Save Searches and receive new technology matches

Inventors

  • Arkin, Michelle R.

Other Information

Keywords

14-3-3, protein-protein interactions, drug discovery

Categorized As