Accurate current measurement is crucial in many biosensing applications, such as the detection of neurotransmitters and the monitoring of intercellular molecular dynamics. This need has become even more critical recently with single molecule biosensors where sub-pA signal currents are superimposed on a slowly varying nA to µA background current, as is the case with nanopores. As such, the readout circuitry requires wide dynamic range (>120dB) and high linearity (>14b) albeit often with low bandwidth (a few Hz to kHz).
Researchers from UC San Diego have developed a very wide dynamic range current measurement for sensors, including biomedical and other sensor applications. This patent-pending invention achieves 7ppm Integral nonlinearity (INL) and 160dB dynamic range (100fA to 10µA) resulting in state-of-the-art performance in terms of normalized conversion time for a 1nA current (0.04ms) and Schreier FoM (197dB) demonstrating an energy efficient, wide dynamic range, high linearity design for current input biosensors.
This work provides a very wide dynamic range current measurement for sensors, including biomedical and other sensor applications.
UC San Diego is seeking commercial partners to develop this patent pending technology.
|Patent Cooperation Treaty||Published Application||2019060461||03/28/2019||2018-069|