Novel Sources of Hematopoietic Progenitor Cells

Tech ID: 30298 / UC Case 2018-470-0

Summary

UCLA researchers in the Department of Urology have developed a novel method of collecting hematopoietic stem cells from deceased donors that preserves the donor body and organs for further donations.

Background

Hematopoietic stem cell (HSC) transplantation is growing into a multi-billion-dollar market worldwide. While harvesting HSCs from live patients are routinely practiced, there’s enormous potential in harvesting HSCs from deceased donors for medical and research purposes. Current approaches to harvesting HSCs from deceased donors involve resecting the cadaver, removing bone fragments and tissues using highly specialized process and aspirating bone marrows. These processes are difficult to perform, and cause damages to cadaver and organs that can be donated.

Innovation

UCLA researchers have developed a novel method of harvesting HSCs from deceased donors. This method involves using mobilizing agents to bring HSCs into the circulation of the deceased donor, then collecting peripheral blood HSCs from the donor via apheresis. If no peripheral blood HSCs are available, bone marrow can be collected for HSC harvesting. This approach does not harm the donor or damage organs that can be donated.

Applications

  • Immune tolerance protocols for organ recipients 
  • Vascularized composite allografts 
  • Hematological malignancies 
  • Gene therapy trials for hemoglobinopathis 
  • Targeted T cell therapies 
  • Storage for nuclear or radiation disasters 
  • Use for inducible pluripotent stem cells 
  • Use for CRISPR engineered HSCs 
  • Use for research into biology and translational studies of HSCs

Advantages

  • Does not harm the deceased
  • Does not damage organs that can be donated 
  • Does not require highly specialized processes

Contact

Learn About UC TechAlerts - Save Searches and receive new technology matches

Inventors

  • Veale, Jeffrey L.

Other Information

Keywords

Hematopoietic Stem Cells, Transplantation, Mobilizing agents, Collection, HSC

Categorized As