Label-Free, Electrochemical Sensor for Detection of Antibiotics in Protein-based Substances

Tech ID: 30098 / UC Case 2018-633-0


Researchers at the University of California, Davis have developed a highly sensitive immunosensor for the detection of chloramphenicol (CAP) residues in milk and other protein-based substances.

Full Description

Current technologies for the detection of antibiotics in proteins include poly(vinyl alcohol-co-ethylene) (PVA-co-PE)-casted membranes. However, these immunosensors are not sensitive enough to detect small amounts of antibiotics. They also require treatment of the proteins to label them. Therefore, there exists a need for a more efficient immunosensor.

Researchers at the University of California, Davis have developed an ultra-sensitive, amperometric immunosensor for the detection of CAP. No pre-treatments are required for testing for residues in milk. This immuno-sensor utilizes a nano-fibrous membrane, which decreases the electron transfer resistance significantly compared with the standard PVA-co-PE-casted membrane.

The antibiotics of CAP provided high selectivity and sensitivity to CAP, while nano-fibrous membrane structures provide ultra-high surface areas and porosity. This design makes the sensor highly sensitive and selective, easy to use and highly responsive.

This immunosensor shows a high sensitivity to even low levels of target antibiotics in label-free milk samples or other proteins. It demonstrates good selectivity, reusability and stability over time. The sensor’s structural platform design also shows promise for fabricating other types of chemical sensors.


  • Label-free sensor for CAP antibiotics in milk proteins


  • System can be used to fabricate other antibiotic or chemical sensors
  • Does not require pretreatment of the milk or other proteins
  • Ultrahigh sensitivity to detect low levels of antibiotics

Patent Status

Patent Pending


Learn About UC TechAlerts - Save Searches and receive new technology matches


  • El-Moghazy, Ahmed
  • Si, Yang
  • Sun, Gang
  • Zhao, Cunyi

Other Information


Biosensors, Bioelectronics, Amperometry, Immunosensors

Categorized As