Methods Comprising Immune System Modulation With Microporous Annealed Particle Gels

Tech ID: 29971 / UC Case 2016-521-0

Summary

UCLA researchers have developed a novel microporous annealed particle (MAP) scaffold that acts as both a tissue growth scaffold and an immune modulatory system. The technology permits continuous, time-encoded, modulation of the immune system delivered injection/implantation of fabricated scaffold, comprised of the MAP gel technology.

Background

Vaccination against target antigens is a crucial part of human health worldwide, and provides the main avenue by which disease is combatted and controlled within the human population. Vaccine technology relies on two critical molecular components: (i) the adjuvant – or immune stimulatory component and (ii) the antigen – the desired target for immunity via antibody production (i.e. acquired immunity). Current vaccine administration requires the use of booster shots (repeat doses) to generate a sustained antibody production against a target antigen, and some target antigens can be difficult to generate immunity against. This may put the patient at risk, as well as others, in the case of communicable diseases. The invention described herein concerns a hydrogel-based material (also referred to as Microporous Annealed Particle or MAP gels) that forms a microporous scaffold structure in situ within the body after injection through a syringe or other delivery method to enable generation of synthetic, injectable therapies and tunable niches for immune cell modulation over sustained periods.

Innovation

UCLA researchers have developed a novel gel that can be used as a scaffold for tissue growth and as a delivery system for immune modulatory factors. The MAP (Microporous Annealed Particle) gel can contain one or more pre-fabricated microgels that can degrade at various stages: degradable, slowly degradable, and non-degradable. Degradable microgels can release molecules either quickly or slowly. Non-degradable or slowly degradable microgels can provide support of vascularization. Additionally, the microgel particles can contain and deliver molecules that act as antigens (proteins, glycoproteins, or lipoproteins) or modulate immune cells.

Applications

  • Immune modulation 
  • Vaccinations
  • Immunotherapy platforms for cancer therapy
  • Immune suppression to aid in organ transplant acceptance without systemic immune suppression (locally deliver corticosteroids and calcineurin inhibitors)

Advantages

  • Synthetic injectable therapies for immune cell modulation over sustained periods
  • Long-lasting
  • High antibody production affinity against target antigen
  • Vascular/lymphatic ingrowth while enabling controlled release of molecules

Patent Status

Patent Pending

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Inventors

  • Segura, Tatiana

Other Information

Keywords

Immunotherapy, immune system, microporous annealed particles, MAP, vaccination, immunosuppression, Microgel, scaffold, immune cell modulation, cancer therapy, adjuvant, antigen, injectable therapy

Categorized As