UCLA researchers in the Department of Bioengineering have developed a new method to generate amphiphilic block copolypeptides.
Block copolymers with amphiphilic character can self-assemble into a variety of micellar structures, including spherical micelles, rodlike micelles, or vesicles. These structures have utility in drug delivery, vesicles for medical diagnostic technologies, and as polymer nanoreactors. Methionine-containing copolymers are of interest for their biocompatibility and ability to be modified to add desirable functionality. However, previous protocols require more complex synthesis protocols and are more limited in scope of functional modifications that can be accomplished.
UCLA researchers led by Professor Timothy Deming have developed a novel strategy to create uniform thioether (methionine) containing block copolypeptides. They have amphiphilic character imparted by selective oxidation and alkylation of methionine residues. This method allows for the preparation of functional block copolypeptides as well as methods to generate micelles, vesicles, hydrogels, and emulsions.
|United States Of America||Issued Patent||9,718,921||08/01/2017||2013-315|
|European Patent Office||Published Application||WO2014134203||09/04/2014||2013-315|
copolymer, alkylation, oxidation, copolymer alkylation, copolymer oxidation, block copolymer, micelle, vesicles, drug delivery, amphipathic, thioether copolymer, methionine copolymers