Researchers in the UCLA Department of Ophthalmology have invented a method of using human embryonic stem cell microvesicles (hESMVs) to induce the regenerative capacity of several tissues, in particular, the ability to induce reconstruction of diseased retinas.
There are currently over 180 million people worldwide suffering from blindness or some form of visual disability, and the demand for new retinal disease treatments is expected to rise quickly. Stem cells are a promising technology in this field; however, this method poses a risk of incorrect differentiation and malignant cell transformation. Human embryonic stem cell microvesicles (hESMVs) are microvesicles released into the extracellular environment by human embryonic stem cells that induce the regenerative capacity of several tissues. hESMVs have been shown to induce the endogenous regenerative capacity of blood, liver, kidney, and lung tissues, and to produce similar biological effects than the ESCs from which they are derived. Additionally, ESMVs from cultured mouse ESCs have demonstrated an ability to transfer to RNA and proteins from cell to cell. hESMVs may therefore stimulate regeneration by inducing endogenous Müller cells to repopulate and repair damaged retina, and their use may avoid the possible long-term maldifferentiation of engrafted intact hESCs and eliminate the risk of their malignant transformation.
A research team lead by Dr. Debora B. Farber in the UCLA Department of Ophthalmology has invented a method of using hESMVs to induce the reconstruction of diseased retinas. In vitro testing is underway with preliminary results outlined below. Integrating hESMVs into stem cell-based ocular therapeutics use can avoid the possible maldifferentiation and malignant transformation of engrafted hESCs.
Treatment of retinal degenerative diseases:
|United States Of America||Published Application||20150079047||03/19/2015||2012-189|
Embryonic stem cell microvesicles (ESMVs), ophthalmic diseases, retinal degenerative diseases, regenerative medicine, cell signaling, ERG