Researchers at UCLA have developed chimeric IgG specific for prostate-specific antigen (PSA) in human and mouse cells.
Prostate-specific antigen (PSA) is a substance made by cells in the prostate gland. Physicians use high PSA levels (above 4 nanograms per milliliter) as a blood biomarker for prostate cancer. Given this, a PSA antibody with high specificity to human PSA would benefit clinical diagnosis of prostate cancer.
Researchers at UCLA have developed a chimeric IgG specific antibody for the PSA in human and mouse cells. The variable regions of this antibody are those of the murine monoclonal antibody AR47.47. This novel antibody was expressed in murine myeloma cell lines, and is therefore cost efficient and easy to produce. It is properly assembled and secreted and binds PSA antigen
Specific to PSA
Developed in murine myeloma cell lines:
Antibody has been developed and validated.
Antibody, prostate specific antigen, PSA, prostate cancer biomarker, diagnosis, diagnostic