Multiparametric Imaging with PET Scans Using High Temporal-Resolution Dynamic Data Acquisition and Modeling

Tech ID: 29764 / UC Case 2018-473-0

Abstract

Researchers at the University of California, Davis, have developed a method to acquire and model high temporal resolution (1-2 seconds per frame) dynamic data with PET scans.

Full Description

Current clinical PET scanning methods and data modeling allow for a temporal resolution of 5-10 seconds per frame with compromised image quality. A high temporal resolution dynamic PET scan can attain a higher temporal resolution, around 2 seconds per frame, but currently cannot be adequately resolved. New methodologies and models are needed to obtain and optimize high-resolution dynamic PET scanning data.

Researchers at the University of California, Davis, have developed a method to acquire and model high temporal resolution PET scans that are a function of temporal and spatial locations. This model is able to directly estimate blood flow and blood volume from the dynamic PET data using a single tracer injection. Using this method, for example, one can obtain simultaneous imaging of blood flow and glucose metabolism using a single dynamic 18F-FDG PET scan. This has applications in characterization of flow-metabolism mismatch or coupling in aggressive tumors, myocardial viability, and brain function in neurodegenerative diseases.

Applications

  • Data analysis of high temporal resolution PET scans
  • Single tracer multiparametric imaging (e.g., perfusion-metabolism imaging by 18F-FDG)
  • Blood flow imaging and analysis
  • Characterization of tumor aggressiveness in cancer therapy
  • Myocardial viability in coronary artery disease
  • Brain function in neurodegenerative diseases

Features/Benefits

  • Derives blood flow without a flow-specific tracer
  • Allows for a reduced imaging time, cost, and radiation dose
  • Requires only one tracer injection
    • Applicable to any radiotracers
  • Is effective in all regions, including regions where extraction fraction is low
  • Applicable to all existing clinical PET scanners

Related Materials

Patent Status

Patent Pending

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Inventors

  • Wang, Guobao

Other Information

Keywords

PET scan, high temporal resolution, time-varying model, multiparametric imaging, dynamic data, single tracer

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