UCLA researchers in the Department of Neurology and Medicine have developed a novel approach is to detect and measure neuroinflammation.
Persistent brain inflammation (neuroinflammation) contributes to Alzheimer disease (AD) and many forms of brain injury. The current methods of trying to detect and measure neuroinflammation are expensive and invasive tests. Besides, ageneral screen for neuroinflammation is needed to capture the presence of neurodegenerative diseases at presymptomatic stages.
The inventors have developed a novel approach to detect and measure neuroinflammation by extracting total plasma extracellular vesicles (PEVs) and an assay for both glial and neural specific markers that respond to neuroinflammation in AD. This method enriches EV biomarkers but avoids the quantitative losses and variable yields associated with neural and glial exosome capture and purification that result in complex normalization issues. For amyloid, they use the broader astrocytic and neural response to amyloid to distinguish the response to beta amyloid from a general response to other types of injury.
Neuroinflammation, brain injury, amyloid, plasma extracellular vesicles, biomarker, Alzheimer disease, neurodegenerative