ABSTRACT: Ultrathin calcinated films on a gold surface for highly effective laser desorption/ionization of biomolecules

Tech ID: 29664 / UC Case 2010-561-0


Methods to form a nanoscale calcinated silicate film fabricated on a gold substrate for highly effective, matrix-free laser desorption ionization mass spectrometry (LDI-MS) analysis of biomolecules. The calcinated film is prepared by a layer-by-layer (LbL) deposition/calcination process wherein the thickness of the silicate layer and its surface properties are precisely controlled. The film exhibits outstanding efficiency in LDI-MS with extremely low background noise in the low-mass region, allowing for effective analysis of low mass weight samples and detection of large biomolecules including amino acids, peptides and proteins. The silicate gold substrate presents a marked advance in the development of matrix-free mass spectrometric methods and is uniquely suited for analysis of biomolecules over a broad mass range with high sensitivity.

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 9,671,409 06/06/2017 2010-561


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mass spectrometry

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