ABSTRACT: Interventions to mimic the effects of calorie restriction

Tech ID: 29575 / UC Case 2000-178-0


Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent RE39,436 12/19/2006 2000-178
United States Of America Issued Patent 6,406,853 06/18/2002 2000-178


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