Due to the year-to-year increase in skin cancer incidences and dramatic decrease in survival, once the melanoma has metastasized, a preventative treatment for skin cancer would be significant. Currently, the only defenses against melanoma are applying sun protection factor (SPF) regularly and protecting oneself from direct sun exposure. In a 2015 national survey conducted by the Center for Disease Control and Prevention (CDC), 34% of adults reported using SPF 15 or higher and 35% of adults reported having a sunburn in the past year.
UC Berkeley researchers have discovered active antiproliferative compounds that can be applied post-sunburn to prevent the growth and metastases of melanoma and therefore, could reduce the number of melanoma incidences per year. Based on preliminary data, they are developing a compound cocktail composed of active lead compounds to develop an anti-proliferative and cytostatic topical treatment of melanoma to slow down tumor development.