Pharmacophore analysis through examination of Joint Pharmacophore Space of chemical compounds, targets, and chemical/biological properties.
Despite steady and significant increases in R&D spending, an increase in the number of new drug applications and approvals has not been seen. Current target-driven approaches to drug discovery limit focus to a single target and have phenotypic effects such as toxicity and low efficacy that are discovered too late in the discovery process. As a result, current interest is shifting towards evaluating biological properties at the onset and attempting to gain a global understanding of the binding activity between compounds and targets. There have been a number of attempts to understand the relationship between drug chemical structures and target proteins, including pharmacophore based screening. A key weakness of existing pharmacophore based technologies is its ability to analyze compounds only on target-by target basis, aimed at extracting and optimizing a specific pharmacophore. Often, multiple pharmacophoric targets need to be analyzed in the search for drugs against diseases such as cancer or AIDS.
|United States Of America||Issued Patent||9,218,460||12/22/2015||2011-077|
indpharma, Pharma, Pharmacaphoric, Chemical Properties, Drug Applications, Drug Design, Blood Brain Barrier, Silico Prediction, Drug Discovery, Molecular Classification, Cancer, Aids, Drug