NOVEL SMALL MOLECULE COMPOUNDS AND TARGET FOR TREATMENT OF AIRWAY HYPERRESPONSIVENESS IN ASTHMA

Tech ID: 27567 / UC Case 2016-026-0

Invention Novelty

Novel small molecule compounds that modulate a new target for the treatment of asthma. 

Value Proposition

Despite its high prevalence, current therapeutic options for asthma are quite limited. Current therapies converge on modulation of the intracellular actin-myosin cross-bridging.  The novel pathway identified by our investigators targets the interaction of the cell and the extracellular matrix to impair the ability of smooth muscle to transmit tension effectively.  Therefore, this pathway has both the ability to independently mitigate airway contraction as well as the ability to adjunctively enhance the efficacy of current treatment regimens.

This novel invention provides the following advantages:

  • Decreased possibility of side effects due to high selectivity of compound and identification of a specific target
  • Small molecule therapy effective at the cellular level
  • Suitable for treating severe asthma

Technology Description

Investigators at the University of California, San Francisco have identified a novel target for the treatment of asthma and have developed novel small molecule inhibitors to this target. Delivery of low affinity inhibitors to this novel target has been shown to reduce the magnitude of airway narrowing in vivo in mice sensitized and challenged with ovalbumin, a widely used model of allergic asthma. In the same model, we found that mice with a specific deletion of this target in smooth muscle also have reduced airway narrowing. The ability of these novel compounds to inhibit cell adhesion mediated by this target was also demonstrated in vitro in colon carcinoma cell lines.  

Looking for Partners

To develop and commercialize the small molecules as an effective treatment for asthma. 

Stage of Development

Preclinical.

Related Materials

Data Availability

Under NDA/CDA.

Patent Status

Country Type Number Dated Case
United States Of America Published Application 20190144386 05/16/2019 2016-026
Canada Published Application 2016-026
European Patent Office Published Application 2016-026
Patent Cooperation Treaty Published Application WO2019178248 09/19/2019 2018-073
 

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Other Information

Keywords

Asthma, Small Molecule, Cell Adhesion Inhibition, Airway Hyperresponsiveness

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