UCLA researchers have identified a set of genomic markets that identify a group of human cancer cell lines more likely to respond to ERK1/2 inhibitors. These markers are believed to be critical in identifying those patients that will most likely respond to ERK1/2 inhibition used in cancer therapy.
Extracellular signal-regulated kinase (ERK) is a kinase that activates many downstream targets through phosphorylation. The ERK-signaling pathway (also referred to as MAPK-signaling pathway) mediates various cellular responses, including cell proliferation, differentiation, growth, migration, and survival. This pathway is activated in many types of cancer. Due to the prevalence of the pathway, it is being explored for cancer therapy. However, since the pathway is found activated in so many types of tumors, there is a need to for a reliable method or diagnostic tool to identify which tumor types are most likely to respond to ERK inhibition.
Diagnostic tool to:
Small Molecules/Pharmaceuticals, Cancer Therapy, Biomarkers, Synergistic Interacting, ERK-signaling pathway, Drug-Response Prediction