Novel Methods to Prevent and Treat Liver and Colon Cancer

Tech ID: 27056 / UC Case 2016-363-0

Abstract

Researchers at the University of California, Davis have developed a method to treat liver and colon cancer using natural or synthetic retinoids in combination with histone deacetylase inhibitors.

Full Description

The incidence of liver and colon cancer is rising due to obesity and metabolic syndrome. It has been found that the gut microenvironment is altered due to unhealthy diet in animals with dysbiosis, lack of nutrients, and dysregulated bile acid synthesis. Despite this correlation, most treatments for liver and colon cancer (such as a colectomy or chemotherapy) do not attempt to address the alteration of the gut microenvironment as a form of recovery.

Researchers at the University of California, Davis have developed a method to treat colon and liver cancer by using retinoids and histone deacetylase inhibitors (HDAC inhibitors) using both natural compounds and synthetic chemicals. In addition, the researchers have uncovered novel mechanism for such anti-cancer effects. Retinoids and HDAC inhibitors can work through specific microRNAs (which are tumor suppressive) to induce apoptosis and arrest of liver and colon cancer cells. Additionally, they reduce inflammation and improve metabolism. The treatment has been successfully tested in vitro in human colon and liver cancer cells, ex vivo in human colon and liver biopsies and in vivo in specific knockout mice as well as xenograt tumor models.

Applications

  • Prevention and treatment of colon and liver cancer

Features/Benefits

  • Target gut microbiota and gut-liver axis
  • Reversing the pathways that are abnormally occurred in both colon and liver cancer
  • Early diagnosis
  • Prevent by reducing inflammation and boost metabolism
  • Cancer treatment

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 2019-03077 10/10/2019 2016-363
Patent Cooperation Treaty Published Application 2018089861 05/17/2018 2016-363
 

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Inventors

  • Wan, Yu-Jui Yvonne

Other Information

Keywords

retinoids, histone deacetylase inhibitors, HDAC inhibitors, colon cancer, liver cancer, protein deacetylase, tumor suppressors, microRNAs, gut-liver axis, gut microbiota, type 2 diabetic mellitus, metabolism, inflammation

Categorized As