This novel brain stimulation device enhances motor function after stroke by modulating the neural network to be more excitable in a task-dependent manner.
Stroke is the leading cause of motor disability in the United States, affecting over 700,000 patients each year. While there have been important strides taken towards optimizing rehabilitation, a substantial proportion of patients continue to experience significant disability. Therefore, it is critical to develop novel technologies to improve motor function after stroke.
Although other neuromodulatory techniques (tDCS: transcranial direct current stimulation, TMS: transcranial magnetic stimulation, ECS: epidural cortical stimulation, PNS: peripheral nerve stimulation) have shown some promise in promoting motor learning and recovery, results have been inconsistent and marginal. Importantly, these techniques use an ‘open-loop stimulation’ design where the electric stimulation is continuously turned on for an extended period of time. As a result stimulation is uncoupled to behavior and is unsuited for task-based function.
UCSF investigators have developed a closed loop stimulation neural interface device to restore function and reduce disability after stroke for patients with moderate impairment. “Closed-loop” stimulation (CLS) directly targets and enhances specific patterns of neural activity, coupling electrical stimulation to task-based brain activity. UCSF researchers have identified neural activities associated with motor learning and function and have generated algorithms to target and enhance stimulation. Using a rodent model of stroke, researchers have shown that their CLS technique generates improved forelimb reaching function after stroke.
To develop & commercialize the technology as medical device
Animal data available under CDA
|United States Of America||Published Application||20190232061||08/01/2019||2016-130|
|European Patent Office||Published Application||3458147||03/27/2019||2016-130|
|Patent Cooperation Treaty||Published Application||WO2020018912||01/23/2020||2016-130|
|Patent Cooperation Treaty||Published Application||WO2017223564||12/28/2017||2016-130|
Stroke, Brain injury, Motor learning, Motor recovery, Close-loop stimulation, Brain stimulation, Neural plasticity