Researchers at the University of California Davis have demonstrated that immature astrocytes generated from human pluripotent stems cells, promote oligodendrocyte lineage progression via TIMP-1 secretion.
Astrocytes, once considered passive support cells, are increasingly appreciated as dynamic regulators of neuoronal development and function. Their ability to regulate oligodendrocytes, or proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) is less understood.
Researchers at the University of California Davis have demonstrated that immature, rather than mature, astrocytes generated from human pluripotent stems cells, promote oligodendrocyte lineage progression via TIMP-1 secretion. Our researchers have further demonstrated that human astroglia, generated from hiPSCs, are highly protective against neonatal brain injury and improve functional outcome. Our findings suggest stage-specific developmental interactions between astroglia and oligodendroglia, with important therapeutic implications for promoting myelinogenesis.
Country | Type | Number | Dated | Case |
United States Of America | Published Application | 20190099452 | 04/04/2019 | 2016-723 |
Astrocytes, stem cells, neuronal development, neonatal brain injury, astroglia, oligodendroglia, myelinogenesis, pluripotent stem cells