|United States Of America||Issued Patent||10,119,148||11/06/2018||2013-816|
Plant-pathogen relationships have been studied meticulously for many years because fungi are notorious for causing detrimental yield losses. Many have taken a biotechnological approach to combatting fungal infections by genetically engineering fungal-resistant genes into plants. The market segment of genomic-enabled products is projected to grow 10% annually and reach $38.6B by 2019.
UCR Researchers have discovered the underlying mechanism of action of Botrytis cinerea, a fungal pathogen that causes grey mold disease in various plants and crops. They’ve identified novel non-protein effectors, small RNAs, that silence specific genes in the host. These fungal sRNAs are transferred into the host cells to suppress its immunity and achieve full infection. With this insight, we can genetically engineer plants to successfully combat harmful pathogenic attacks by inhibiting small RNA effectors.
small RNA, sRNA, small noncoding RNA, transposon, transposable elements, TE, effector, pathogen, fungal pathogen, pathogenicity, host immunity, RNA interference, RNAi, gene silencing, plant immunity, grey mold disease