Small RNAs From Fungal Pathogents Act As Effector Molecules To Suppress Host Immunity

Tech ID: 25294 / UC Case 2013-816-2

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 10,119,148 11/06/2018 2013-816


Brief Description


Plant-pathogen relationships have been studied meticulously for many years because fungi are notorious for causing detrimental yield losses. Many have taken a biotechnological approach to combatting fungal infections by genetically engineering fungal-resistant genes into plants. The market segment of genomic-enabled products is projected to grow 10% annually and reach $38.6B by 2019.



Brief Description:

UCR Researchers have discovered the underlying mechanism of action of Botrytis cinerea, a fungal pathogen that causes grey mold disease in various plants and crops. They’ve identified novel non-protein effectors, small RNAs, that silence specific genes in the host. These fungal sRNAs are transferred into the host cells to suppress its immunity and achieve full infection. With this insight, we can genetically engineer plants to successfully combat harmful pathogenic attacks by inhibiting small RNA effectors.



  • Insight into infection-reversal via inhibiting transfer of sRNAs from fungal pathogens
  • Gradual elimination of antimicrobial agent and pesticide use
  • One time genetic engineering – will pass on to future generations


  • Genetic engineering of plants for research and agricultural use


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Other Information


small RNA, sRNA, small noncoding RNA, transposon, transposable elements, TE, effector, pathogen, fungal pathogen, pathogenicity, host immunity, RNA interference, RNAi, gene silencing, plant immunity, grey mold disease

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