Catalytic Coupling Reactions Using Frameworks with Open-Metal-Sites

Tech ID: 25267 / UC Case 2009-757-0


UCLA researchers in the Department of Chemistry and Biochemistry have developed a group of novel organic framework-based catalysts used in coupling reactions. These catalysts demonstrate high efficiency and specificity, combined with the great chemical stability and reproducibility seen with organic framework materials.


Coupling reactions are used in organic chemistry to join two hydrocarbons. Because of the importance of hydrocarbons, coupling reactions are widely utilized in the pharmaceutical industry as well as in industrial chemistry. In coupling reactions, a metal catalyst such as Palladium (Pd) is traditionally used. Other traditionally used catalyst include Cr (II), Pb (II), Mn (IV), Ti (II), and Ni (II). Problems using these metal catalysts include poor yields, poor selectivity, environmentally-unfriendly, and restricted operating conditions. A better catalytic system for coupling reactions will be highly beneficial to both the pharmaceutical and industrial industry by improving material economy and minimizing environmental toxicity.


Dr. Omar Yaghi and colleagues at UCLA have developed a copper (Cu)-based metal organic framework and metal organic polyhedra that can be used as a catalyst in a homo-coupling synthesis reaction to generate biaryls. The catalyst was demonstrated to have up to 95% conversion and 90% selectivity as well as having high chemical stability.


• Coupling-reaction catalyst
• Drug Precursor Synthesis


• Copper-based catalyst
• Catalysts are easily produced
• High chemical and temperature stability

State Of Development

A series of Suzuki homo-coupling and Chan-Lam coupling reactions have been successfully performed using various MOFs and MOPs. 

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 9045387 06/02/2015 2009-757


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  • Yaghi, Omar M.

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