Methods of Monitoring and Manipulating the Fate of Transplanted Cells

Tech ID: 25147 / UC Case 2015-660-0

Background

Tumor initiation and progression into metastasis are accompanied by complex structural changes in the extracellular matrix and cellular architecture that alters the stiffness in the microenvironment of the cell.

Technology Description

The researchers at the University of California, Irvine, created a Mechanical Responsive Cell System (MRCS) having reporter molecules that can measure the changes in the stiffness in the local microenvironment in vivo. The reporter molecules can be genes, proteins, antibodies, biomarkers, therapeutic agents and homing agents, which can monitor and communicate the progression of cancer through signals, images and data back to the user who can then monitor and control the fate of the transplanted cells.

Application

The MRCS can be used to monitor the initiation and progression of the following:

  1. Cancer including metastases, especially, breast and lung;
  2. Cardiovascular disease including, atherosclerosis;
  3. Antibodies in cancer therapy;
  4. Therapeutic enzymes in the treatment of tissue fibrosis;
  5. Treatment for diabetes;
  6. Promoting wound healing;
  7. Regenerative medicine;
  8. Immune related disease; etc...

    Advantages

    Patent Status

    Patent Pending

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Other Information

Keywords

Mechanical responsive cell system, transplantation, reporter, cell therapy, mesenchymal stem cell, engineered cell, biomarker, gene, therapeutic, probe, transplanted cell

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