Optical Cavity PCR

Tech ID: 24918 / UC Case 2015-137-0

Patent Status

Patent Pending

Brief Description

Outbreaks of infectious diseases especially require diagnostic tools that can be used at the point-of-care (POC). Polymerase chain reaction (PCR) is sensitive and allows accurate diagnoses, but developing simple and robust PCR methods that can be used at POC remains a challenge. In particular, slow thermal cycling capability and high power consumption continue to be barriers.

 

Researchers at UC Berkeley have developed optical cavity PCR to address these challenges. This technology allows ultrafast cycling with low power consumption, high amplification efficiency and a simple fabrication process, enabling its use as a POC device.

 

Suggested uses

 

  • Diagnostic tool for use at point-of-care
  • Nucleic acid amplification and quantification using Ultrafast PCR
  • Isothermal amplification including loop-mediated isothermal amplification (LAMP)
  • Recombinase polymerase amplification (RPA)
  • Research tool

 

Advantages

  • Rapid cycling
  • Low power consumption
  • Temperature uniformity of reaction
  • Reliable and portable means to perform PCR

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Inventors

  • Lee, Luke P.
  • Son, Jun Ho

Other Information

Keywords

Diagnostic, point-of-care, infectious disease, PCR, LAMP, RPA, microfluidic

Categorized As