Outbreaks of infectious diseases especially require diagnostic tools that can be used at the point-of-care (POC). Polymerase chain reaction (PCR) is sensitive and allows accurate diagnoses, but developing simple and robust PCR methods that can be used at POC remains a challenge. In particular, slow thermal cycling capability and high power consumption continue to be barriers.
Researchers at UC Berkeley have developed optical cavity PCR to address these challenges. This technology allows ultrafast cycling with low power consumption, high amplification efficiency and a simple fabrication process, enabling its use as a POC device.
Diagnostic, point-of-care, infectious disease, PCR, LAMP, RPA, microfluidic