Prevention and Reversal of Cell Aging

Tech ID: 24887 / UC Case 2015-127-0

Patent Status

Country Type Number Dated Case
United States Of America Published Application 20180051253 02/22/2018 2015-127
European Patent Office Published Application WO 2016/149672 09/22/2016 2015-127
Patent Cooperation Treaty Published Application WO2016149672 09/22/2016 2015-127
 

Brief Description

By 2050 the number of people in the world that will be aged 65 or older is expected to nearly triple to about 1.5 billion, representing 16% of the world’s population. One aspect of aging involves a diminished capacity to repair tissues after injury. This diminished capacity is evident in certain conditions that occur with aging, such as anemia, sarcopenia (loss of muscle mass), and osteoporosis. Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance. Adult stem cells mostly reside in a metabolically inactive quiescent state to preserve their integrity, but convert to a metabolically active proliferative state to replenish the tissue. The signals that trigger stem cells to exit the cell cycle and re-enter quiescence, and the signal transduction leading to the transition remain elusive however.

UC Berkeley researchers have developed methods of reversing and preventing the aging of stem cells by activating the mitochondrial unfolded protein response in a stem cell. Other aspects of the technology relate to methods of preventing and/or reversing tissue degeneration or injury.

 

Suggested uses

  • Drug targets for the treatment of aging diseases or tissue degeneration or injury
  • Study of age-related diseases

 

Advantages

  • Specific target for anti-aging compound screens may enable rationale design of drug targets

Publication

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

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Inventors

  • Chen, Danica

Other Information

Keywords

Aging; stem cell; UPR, mitochondria, tissue degeneration

Categorized As

Additional Technologies by these Inventors