Small Volume Liquid Manipulation, Method, Apparatus And Process

Tech ID: 24712 / UC Case 2007-673-0

Brief Description

Efficient multipurpose device for bulk flow of materials and separation.

Background

Devices using electrokinetic properties (electrophoresis, dielectrophoresis, electroosmosis and electrothermal convection) have been used to manipulate fluids and particles. Electrophoresis is a method used to manipulate components of a mixture of charged particles (proteins, DNAs or RNAs) in an electric field. There have been many methods proposed for bulk flow of materials and separation, but there is still a lack of an efficient multipurpose device. 

Description

In this invention, particles are separated, concentrated or mixed within a fluid by means of a fluid-containing cell having a longitudinal axis, a cross-sectional area generally perpendicular to the longitudinal axis, and at least one particle motivating force directionally interacting with at least one recurrent circulating fluid flow generally aligned with the longitudinal axis within the fluid-containing cell. 

Advantages

·         Ability to generate fluid flow or particle separation

·         Microliter volumes can be manipulated

·         Electrothermal convection or electroosmosis used 

Applications

·         Mixing of microliter or nanoliter volume protein solutions

·         Separation and detection of small populations of pre-cancerous cells in body fluids

·         Concentration of DNA particles in a PCR apparatus (improved DNA detection)

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 8,246,802 08/21/2012 2007-673
 

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Keywords

electrokinetic, particle mixing, fluid flow, particle separation, DNA, protein, indpharma

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